生化暨生物科技研究所 -- 謝逸憲老師
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謝逸憲老師


 

 

謝逸憲 副教授

Yi-Hsien Hsieh


          聯絡方法  

 


  專長介紹








學歷

中山醫學大學生化暨生物科技所博士 (2001-2006)
中山醫學大學生化暨生物科技所碩士(1999-2001)

經歷:

中 國醫藥大學附設醫院分子醫學中心博士後研究(2007-2009)
中山醫學大學生化暨生物科技研究所助理教授(2009-2012)

現任:

中山醫學大學生化暨生物科 技研究所副教授

中山醫學大學醫學系生化學科所副教授

專長:

腫瘤生物學、訊息傳遞、細胞和基因毒理

研究計畫:

國科 會三年期研究計畫100-103年度專題研究計畫
NSC 100-2313-B-040 -001-MY3 (主持人)
國科 會三年期研究計畫101-104年度專題研究計畫
NSC 101-2313-B-040 -001 -MY3
102 學年度中山醫學大學跨院際合作計畫(彰基)
(CSMU-CCH-101-005主持人)
103 學年度中山醫學大學跨院際合作計畫(彰基)
(CSMU-CCH-102-05主持人)
研究方向:

1.

研究天然 物抑制腫癌細胞生長和侵襲之分子機轉

2.

研究前列 腺癌和子宮頸癌之新穎腫瘤基因的生物功能和基因調節機制

3.

研究肝癌之新穎腫瘤基因的生物功能和基因調節機制

聯絡電話:04-24730022- 11673
E-mail:
hyhsien@csmu.edu.tw

  

 

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學術著作目錄

Research Publication

1

Hsieh SC, Tsai JP, Yang SF, Tang MJ, Hsieh YH*. Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression. Amino Acids. 2014. Accept. (IF:3.53; Ranking: 97/291)

2

Huang HC, Tsai LL, Tsai JP, Hsieh SC, Yang SF, Hsueh JT, Hsieh YH*. Licochalcone A inhibits the migration and invasion of human lung cancer cells via inactivation of the Akt signaling pathway with downregulation of MMP-1/-3 expression. Tumour Biol. 2014. Accept  (IF:2.84; Ranking: 93/202)

3

Cheng CY, Chou YE, Ko CP, Yang SF, Hsieh SC, Lin CL, Hsieh YH*, Chen KC. Metastasis tumor-associated protein-2 knockdown suppresses the proliferation and invasion of human glioma cells in vitro and in vivo. J Neurooncol. 2014.Accept (IF:2.787; Ranking: 71/194)

4

Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Wang HL, Kuo SC, Chen CH, Yu YL, Hung MC. EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell. 2014. 30(2):224-37 (IF:10.34; Ranking: 3/41)

5

Tsai JP, Hsiao PC, Yang SF, Hsieh SC, Bau DT, Ling CL, Pai CL, Hsieh YH*. Licochalcone A Suppresses Migration and Invasion of Human Hepatocellular Carcinoma Cells through Downregulation of MKK4/JNK via NF-κB Mediated Urokinase Plasminogen Activator Expression. PLOS ONE. 2014. 9 (1); e86537. (IF:3.53; Ranking: 97/291)

6

Tsai HT, Hsin CH, Hsieh YH, Tang CH, Yang SF, Lin CW, Chen MK. Impact of interleukin-18 polymorphisms -607A/C and -137G/C on oral cancer occurrence and clinical progression. PLoS One. 2013 13;8(12):e83572. (IF:3.53; Ranking: 97/291)

7

Hsiao PC, Hsieh YH*, Chow JM, Yang SF, Hsiao M, Hua KT, Lin CH, Chen HY, Chien MH. Hispolon Induces Apoptosis through JNK1/2-Mediated Activation of a Caspase-8, -9, and -3-Dependent Pathway in Acute Myeloid Leukemia (AML) Cells and Inhibits AML Xenograft Tumor Growth in Vivo. J Agric Food Chem. 2013, 61(42):10063-73. (IF:2.9; Ranking: 1/57)

8

Hsin CH, Wu BC, Chuang CY, Yang SF, Hsieh YH, Ho HY, Lin HP, Chen MK, Lin CW. Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells. BMC Complement Altern Med. 2013, 13(1):234 (IF2.08; Ranking: 7/22)

9

Yu YL, Su KJ, Hsieh YH, Lee HL, Chen TY, Hsiao PC, Yang SF. Effects of EZH2 Polymorphisms on Susceptibility to and Pathological Development of Hepatocellular Carcinoma. PLoS One. 2013 10;8(9):e74870. (IF:3.53; Ranking: 97/291)

10

Hsieh SC, Huang MH, Cheng CW, Hung JY, Yang SF, Hsieh YH*.α-mangostin induces mitochondrial 1 dependent apoptosis in human hepatoma SK-Hep-1 cells through inhibition of p38 MAPK pathway. Apoptosis. 2013. 18(12):1548-60  (IF:3.62; Ranking: 100/291)

11

Chou RH, Hsieh SC, Yu YL, Huang MH, Huang YC, Hsieh YH*. Fisetin inhibits migration and invasion of human cervical cancer cells by down-regulating urokinase plasminogen activator expression through suppressing the p38 MAPK-dependent NF-kB signaling pathway. PLoS One. 2013;8(8):e71983. (IF:3.53; Ranking: 97/291)

12

Tung MC, Hsieh SC, Yang SF, Cheng CW, Tsai RT, Wang SC, Huang MH, Hsieh YH*. Knockdown of Lipocalin-2 Suppresses the Growth and Invasion of Prostate Cancer Cells. Prostate. 2013. 73(12):1281-90. (IF:3.56; Ranking: 10/75)

13

Tsai SJ, Hwang JM, Hsieh SC, Ying TH, Hsieh YH*. Overexpression of myeloid zinc finger 1 suppresses matrix metalloproteinase-2 expression and reduces invasiveness of SiHa human cervical cancer cells. Biochem Biophys Res Commun. 425; 462467. 2012. (IF:2.48; Ranking:39/79)

14

Chien MH, Ying TH, Yang SF, Yu JK, Hsu CW, Hsieh SC, Huang YC, Hsieh YH*. Lipocalin-2 induces apoptosis in human hepatocellular carcinoma cells through activation of mitochondria pathways. Cell Biochemistry and Biophysics. 2012. 64(3):177-86. (IF:3.73; Ranking:18/74)

15

Chung TT, Yeh CB, Li YC, Su SC, Chien MH, Yang SF, Hsieh YH*. Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features. PLoS One. 7(3):e33517. 2012. (IF:3.53; Ranking: 97/291)

16

Ying TH, Yang SF, Tsai SJ, Hsieh SC, Huang YC, Bau DT, Hsieh YH*. Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway. Arch Toxicol. 86(2):263-273. 2012 (IF:4.67; Ranking:8/83)

17

Yeh CB, Hsieh MJ, Hsieh YH, Chien MH, Chiou HL, Yang SF. Antimetastatic effects of norcantharidin on hepatocellular carcinoma by transcriptional inhibition of MMP-9 through modulation of NF-kB activity. PLoS One. 7(2):e31055. 2012. (IF:3.53; Ranking: 97/291)

18

Chien MH, Ying TH, Hsieh YH, Lin CH, Shih CH, Wei LH, Yang SF. Tumor-associated carbonic anhydrase XII is linked to the growth of primary oral squamous cell carcinoma and its poor prognosis. Oral Oncol. 48(5):417-423, 2012. (IF:2.86; Ranking:8/81)

19

Weng CJ, Hsieh YH, Chen MK, Tsai CM, Lin CW, Yang SF. Survivin SNP-carcinogen interactions in oral cancer. J Dent Res. 91(4):358-63. 2012. (IF:3.48; Ranking:3/81)

20

Tee YT, Wang PH, Tsai HT, Lin LY, Lin HT, Yang SF, Hsieh YH*, Ying TH. Genetic polymorphism of urokinase-type plasminogen activator is interacting with plasminogen activator inhibitor-1 to raise risk of cervical neoplasia. J Surg Oncol. 106:204208. 2012. (IF:2.27; Ranking:51/199)

21

Hsieh YS, Tsai CM, Yeh CB, Yang SF, Hsieh YH, Weng CJ. Survivin T9809C, an SNP Located in 3'-UTR, Displays a Correlation with the Risk and Clinicopathological Development of Hepatocellular Carcinoma. Ann Surg Oncol. 19:S625S633.2012. (IF:4.16; Ranking:9/199)

22

Chang CC, Wang PH, Su PH, Lin DB, Ying TH, Yang SF, Hsieh YH*. Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. Clin Chem Lab Med. 49:1655-1660, 2011. (IF:2.069; Ranking:9/31)

23

Chien MH, Yeh KT, Li YC, Hsieh YH, Lin CH, Weng MS, Kuo WH, Yang SF. Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma. J Surg Oncol. 104:299-304. 2011. (IF:2.27; Ranking:51/199)

24

Chen TY, Li YC, Liu YF, Tsai CM, Hsieh YH, Lin CW, Yang SF, Weng CJ. Role of MMP14 Gene Polymorphisms in Susceptibility and Pathological Development to Hepatocellular Carcinoma. Ann Surg Oncol. 18(8):2348-56. 2011. (IF:4.16; Ranking:9/199)

25

Li LY, Chen H, Hsieh YH, Wang YN, Chu HJ, Chen YH, Chen HY, Chien PJ, Ma HT, Tsai HC, Lai CC, Sher YP, Lien HC, Tsai CH, Hung MC. Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes. Cancer Res. 71(12):4269-4279. 2011. (IF:9.28; Ranking:10/202)

26

Yeh CB, Tsai HT, Chen YC, Kuo WH, Chen TY, Hsieh YH, Chou MC, Yang SF. Genetic polymorphism of CCR2-64I increased the susceptibility of hepatocellular carcinoma. J Surg Oncol. 102(3):264-70. 2010. (IF:2.27; Ranking:51/199)

27

Wang PH, Liu YF, Tsai HT, Tee YT, Lin LY, Hsieh YH, Yang SF. Elevated plasma osteopontin level is associated with pelvic inflammatory disease. Reprod Sci. 17(11):1052-8. 2010. (IF:2.586; Ranking:11/26)

28

Weng CJ, Tsai CM, Chen YC, Hsieh YH, Lin CW, Liu YF, Su SC, Chen MK, Yang SF. Evaluation of the association of urokinase plasminogen activator system gene polymorphisms with susceptibility and pathological development of hepatocellular carcinoma. Ann Surg Oncol. 17(12):3394-401. 2010. (IF:4.16; Ranking:9/199)

29

Kao CC, Chen MK, Kuo WH, Chen TY, Su SC, Hsieh YH, Liu CL, Chou MC, Tsai HT, Yang SF. Influence of glutathione-S-transferase theta (GSTT1) and micro (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan. J Surg Oncol. 102(4):301-7. 2010. (IF:2.27; Ranking:51/199)

30

Hsiao PC, Chen MK, Su SC, Ueng KC, Chen YC, Hsieh YH, Liu YF, Tsai HT, Yang SF. Hypoxia inducible factor-1alpha gene polymorphism G1790A and its interaction with tobacco and alcohol consumptions increase susceptibility to hepatocellular carcinoma. J Surg Oncol. 102(2):163-9. 2010. (IF:2.27; Ranking:51/199)

31

Yang SF, Chen MK, Hsieh YS, Chung TT, Hsieh YH, Lin CW, Su JL, Tsai MH, Tang CH. Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells. J Biol Chem. 285(39):29808-16. 2010. (IF:4.326; Ranking:50/286)

32

Yang SF, Chen MK, Hsieh YS, Yang JS, Zavras AI, Hsieh YH, Su SC, Kao TY, Chen PN, Chu SC. Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases. Food Chem Toxicol. 48(4):1052-8, 2010. (IF:5.326; Ranking:16/128)

33

Weng CJ*, Hsieh YH*, Tsai CM, Chu, YH, Ueng KC, Liu YF, Zavras AI, Su SC, Chen YC, Chen MK, Yang SF. Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma. Ann Surg Oncol. 17(7):1808-15. 2010. (IF:4.16; Ranking:9/199)

34

Hwang JM, Kao SH, Hsieh YH, Li KL, Wang, PH, Hsu, L.S., Liu, J.Y. Reduction of anion exchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells. Molecular and Cellular Biochemistry. 327(1-2):135-44, 2009. (IF:2.168; Ranking:122/178)

35

Chang CC, Chen SC, Hsieh YH, Chen YC, Chen TY, Chu YH, Ma HJ, Chou MC, Tsai HT, Yang SF. Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increasesusceptibility and pathological development of hepatocellular carcinoma. Clin Chem Lab Med. 47(4):412-8, 2009. (IF:2.069; Ranking:9/31)

36

Tsai HT, Tee YT, Hsieh YH, Chiou HL, Lin CW, Tsai HC, Wang PH, Yang SF. Elevated plasma stromal cell-derived factor 1 protein and its gene polymorphism in patients with pelvic inflammatory disease. Reprod Sci. 16(6):610-7, 2009. (IF:2.586; Ranking:11/26)

37

Wu TT, Hsieh YH, Hsieh YS, and Liu JY.* Reduction of PKCa decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma. Journal of Cellular Biochemistry. 103(1): 9-20, 2008. (IF:3.12; Ranking:125/286)

38

Ying TH, Hsieh YH, Hsieh YS, Liu JY. Antisense oligonucleotide Elk-1 suppresses the tumorigenicity of human hepatocellular carcinoma cells. Cell Biology International. 32(2):210-6, 2008. (IF:1.747; Ranking:141/1787)

39

Liu CJ, Hwang JM, Wu TT, Hsieh YH, Wu CC, Hsieh YS, Tsai CH, Wu HC, Huang CY, Liu JY. Anion exchanger inhibitor DIDS induces human poorly-differentiated malignant hepatocellular carcinoma HA22T cell apoptosis. Molecular and Cellular Biochemistry. 308(1-2):117-125, 2008. (IF:2.168; Ranking:122/178)

40

Hsieh, Y.H., Wu, T.T., Huang, C.Y., Hsieh, Y.S., Hwang, J.M., Liu, J.Y. p38 MAPK pathway is involved in Protein Kinase Ca-regulated invasion in human hepatocellular carcinoma cells. Cancer Research. 67(9):4320-4327, 2007. (IF:8.234; Ranking:12/185)

41

Hsieh YH, Wu TT, Huang CY, Hsieh YS, Liu JY. Suppression of tumorigenicity of human hepatocellular carcinoma cells by antisense oligonucleotide MZF-1. Chinese Journal of Physiology. 50(1):9-15, 2007. (IF:0.683; Ranking:71/78)

42

  Wu TT, Hsieh YH., Wu CC., Hsieh YS, Huang CY, Liu JY. Overexpression of Protein Kinase Ca mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis. Clinica Chimica Acta. 382(1-2):54-58, 2007. (IF:2.38; Ranking:6/31)



 

研討會論文

1

Yi-Cheng Huang, Tsung-Ho Ying, Shun-Fa Yang, Yi-Hsien Hsieh. Fisetin Induced Apoptosis of Human Cervical Cancer Cells via Activation of ERK1/2 and Caspase-8/-3 Signaling. (2011) 20屆細胞及分子生物新知研討會。

2

Yi-Cheng Huang, Tsung-Ho Ying, Shun-Fa Yang, Yi-Hsien Hsieh. Lipocalin-2 induces apoptosis in human hepatocellular carcinoma cells. (2011) 26屆生物醫學聯合學術年會

3

Shu-Ching Hsieh, Chen-Li Pai, Shun-Fa Yang, Yi-Hsien Hsieh Licochalcone A suppress invasiveness of human hepatoma cancer cells by inhibiting the urokinase-plasminogen activator/JNK signaling pathway. (2012) 27屆生物醫學聯合學術年會

4

Jyun-Hao Hung, Shun-Fa Yang, Yi-Hsien Hsieh. The in vitro and in vivo apoptotic effects of -mangostin on human hepatoma SK-Hep-1 cells. (2012) 27屆生物醫學聯合學術年會

5

Meng-Ju Tang, Shu-Ching, Yi-Hsien Hsieh. Regulation of Human Hepatocellular carcinoma Progression by Epithelial membrane protein 3 (EMP3), (2013) 生物醫學聯合學術< /span>.(28屆生物醫學聯合學術年會優秀壁報論文 獎)

6

Shu-Ching Hsieh, Shao-Chuan Wang, Yi-Hsien Hsieh. Knockdown of Lipocalin-2 Suppresses the Growth and Invasion of Prostate Cancer Cells. (2013) 28屆生物醫學聯合學術年會

7

Chu-Liang Lin, Yi-Hsien Hsieh. Norcantharidin induces apoptosis in human prostate cancer cells through inhibition of Akt-dependent pathways in vitro and in vivo. (2014) 22屆新知研討會.

8

Shiau-Hua Wen, Yi-Hsien Hsieh. α-mangostin induces cervical cancer cell apoptosis through ROS/MAPK signaling pathways via mitochondrial mediated caspase-dependent mechanism. (2014) 29屆生物醫學聯合學術年會

9

Shin-Huey Lin, Tung-Wei Hung, Horng-Rong Chang, Yi-Hsien Hsieh Pentraxin-3 induces epithelial-mesenchymal transition in human renal fibrosis through activation of JNK-dependent Pathway. (2014) 29屆生物醫學聯合學術年會



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