生化暨生物科技研究所 -- 王朝鐘 老師
:::
王朝鐘 老師

王朝鐘教授 聯絡方式
  專長介紹
學歷: 台大醫學院生化所博士
經歷:

中山醫學院醫研所副所長(1991)

學務長(1992)

醫學系生化科主任 (1988)

生化暨生物科技研究所教授兼所長(1993-2008)

研究發展處研發長 (2008-2010)

中草藥暨保健食品研究開發中心主任

專長:

癌症生化,化學預防 (肥胖,癌症,肝及心血管疾病) 保健食品研究開發

研究:

1.腫瘤促進物質之作用及分子機轉研究

2.化學防癌物質之開發及抑制癌化之分子機轉研究

3.抗癌藥物之發展及促進癌細胞凋謝死亡之機轉研究

4.NO及其衍生物癌化作用之分子機轉研究

5.解毒基因誘導作用之調節機轉研究

6.中草藥抗癌及調節肝臟功能之開發研究

7.抑制心血管疾病天然物開發

8.機能性食品功能性成份,分析作用及機轉研究

9.糖尿病致副病變之機轉及預防研究

10.天然物調控肝臟及體脂肪之機轉

11.肥胖癌症標靶之研究

12.私校研發特色疾病化學預防物質之研究開發

  聯絡: 04-24730022-11670
04-24730022-11883
E-mail:
wcj@csmu.edu.tw

學術著作目錄(近5年)

(A) REFEREED PAPER (*者為SCI)   (近五年-期刊論文)

1.

Hsieh-Hsun Ho, Chi-Sen Chang, Wei-Chi Ho, Sheng-You Liao, Wea-Lung Lin,Chau-Jong Wang (2013). Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB,downregulation of AKT/small GTPase signals and inhibition of NF-κB activity.TOXICOLOGY AND APPLIED PHARMACOLOGY, 266, 76-85. 本人為通訊作者.

2.

Chao-Hsin Lee, Chih-Yi Kuo, Chau-Jong Wang, Chi-Ping Wang, Yi-Ru Lee, Chi-Nan Hung, Huei-Jane Lee (2012). A polyphenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 76, 646-651.

3.

Chin-Yi Kuo, Erl-Shyh Kao, Kuei-Chuan Chan, Huei-Jane Lee, Tsai-Feng Huang, Chau-Jong Wang(2012). Hibiscus Sabdariffa L. extracts reduce serumuric acid levels in oxonate-induced rats. Journal of Functional Foods , 4, 375-381. 本人為通訊作者.

4.

Chiung-Huei Peng, Hong-Chou Chang, Mon-Yuan Yang, Chien-Ning Huang, Shing-Jung Wang, Chau-Jong Wang (2012). Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat. Journal of Functional Foods , In press. 本人為通訊作者.

5.

Hui-Hsuan Lin, Kuei-Chuan Chan, Jenn-Yuan Sheu, Shu-Wen Hsuan, Chau-Jong Wang, Jing-Hsien Chen (2012). Hibiscus Sabdariffa leaf induces apoptosis of human prostate cancer cells in vitro and in vivo. FOOD CHEMISTRY, 132, 880-891. 本人為通訊作者.

6.

Hui-Pei Huang, Chau-Jong Wang, Jen-Pi Tsai, Sheng-Wen Wu, Tung-Wei Hung,Jong-Da Lian, Horng-Rong Chang (2012). Y27632 attenuates the aristolochic acid-promoted invasion and migration of human urothelial cancer TSGH cells in vitro and inhibits the growth of xenografts In vitro. NEPHROLOGY DIALYSIS TRANSPLANTATION , 27, 565-575.

7.

Kuei-Chuan Chan, Cheng-Hsun Wu, Chien-Ning Huang, Kuang-Ping Lan, Wen-Chun Chang Chang, Chau-Jong Wang (2012). Simvastatin Inhibits Glucose-Stimulated Vascular Smooth Muscle Cell Migration Involving Increased Expression of RhoB and a Block of Ras/Akt Signal. CardiovascularTherapeutics , 30, 75-84. 本人為通訊作者.

8.

Li-Sung Hsu, Hsieh-Hsun Ho, Ming-Cheng Lin, Charng-Cherng Chyau, Jih-Shin Peng, Chau-Jong Wang (2012). Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat. FOOD AND CHEMICAL TOXICOLOGY, 50, 3086-3093. 本人為通訊作者.

9.

Ting-Tsz Ou, Chih-Yi Kuo, Charng-Cherng Chyau, Huei-Jane Lee, Jih-Shin Peng, Chau-Jong Wang (2012). Improvement of lipopolysaccharides-induced hepatic injuries and inflammation with mulberry extracts. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, In press. 本人為通訊作者

10.

Tzi-Peng Yang, Huei-Jane Lee, Ya-Ju Chang, Chau-Jong Wang (2012). Mulberry leaf polyphenols extract (MLPE) induced apoptosis involving regulation of AMPK/FASN in p53-negative hepatocellular carcinoma cell. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 60, 6891-6898. 本人為通訊作者.

11.

Yun-Ching Chang, Jeng-Dong Hsu, Wea-Lung Lin, Yi-Ju Lee, Chau-Jong Wang (2012). High incidence of acute promyelocytic leukemia specifically induced by N-nitroso-N-methylurea (NMU) in Sprague-Dawley rats. ARCHIVES OF TOXICOLOGY, 86, 315-327. 本人為通訊作者.

12.

Cheng-Hsun Wu, Ming-Cheng Lin, Hsueh-Chun Wang, Mon-Yuan Yang, Ming-Jia Jou, Chau-Jong Wang (2011). Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells. JOURNAL OF FOOD SCIENCE , 76, 65-72. 本人為通訊作者.

13.

Chih-Yi Kuo, Cheng-Teng Hsu, Cheng-Shiao Ho, Ting-En Su, Ming-Hsun Wu,Chau-Jong Wang (2011). Accuracy and precision evaluation of seven selfmonitoring blood glucose systems. Diabetes Technology & Therapeutics , 13,596-600. 本人為通訊作者.

14.

Chiung-Huei Peng, Charng-Cherng Chyau, Kuei-Chuan Chan, Tsung-HsienChan, Chau-Jong Wang, Chien-Ning Huang (2011). Hibiscus sabdariffa polyphenolic extract inhibits hyperglycemia, hyperlipidemia, and glycationoxidative stress while improving insulin resistance. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 59, 9901-9909. 本人為通訊作者.

15.

Chiung-Huei Peng, Li-Kaung Liu, Chao-Ming Chuang, Charng-Cherng Chyau, Chieng-Ning Huang, Chau-Jong Wang (2011). Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 59, 2663-2671. 本人為通訊作者.

16.

Haw-Wen Chen, Ai-Hsuan Lin, Hsing-Chin Chu, Chien-Chun Li, Chia-Wen Tsai, Che-Yi Chao, Chau-Jong Wang, Chong-Kuei Lii Kai-Li Liu (2011). Inhibition of TNF-α-induced inflammation by andrographolide via down regulation of the PI3K/Akt signaling pathway. JOURNAL OF NATURAL PRODUCTS, 74, 2408-2413

17.

Hsueh-Chun Wang, Chia-Hung Hung, Jeng-Dong Hsu, Mon-Yuan Yang, Shing-Jung Wang, Chau-Jong Wang (2011). Inhibitory effect of whole oat on aberrant crypt foci formation and colon tumor growth in ICR and BALB/c mice. JOURNAL OF CEREAL SCIENCE , 53, 73-77. 本人為通訊作者.

18.

Hui-Hsuan Lin, CW Tsai, Fen-Pi Chou, Chau-Jong Wang, Jing-Hsien Chen(2011). Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells. TOXICOLOGY AND APPLIED PHARMACOLOGY, 250, 336-345.

19.

Hui-Hsuan Lin, Jing-Hsien Chen, Chau-Jong Wang (2011). Chemopreventive Properties and Molecular Mechanisms of the Bioactive Compounds in Hibiscus Sabdariffa Linne. CURRENT MEDICINAL CHEMISTRY, 18, 1245-1254. 本人為通訊作者.

20.

Hui-Hsuan Lin, Jing-Hsien Chen, Feu-Pi Chou, Chau-Jong Wang (2011). Protocatechuic acid inhibits cancer cell metastasis involving the down-regulation of Ras/Akt/ NF-κB pathway and MMP-2 production by targeting RhoB activation. BRITISH JOURNAL OF PHARMACOLOGY , 162, 237-254. 本人為通訊作者.

21.

Hui-Pei Huang, Yun-Ching Chang, Cheng-Hsun Wud, Chi-Nan Hung, Chau-Jong Wang (2011). Anthocyanin-rich Mulberry extract inhibit the gastric cancer cell growth in vitro and xenograft mice by inducing signals of p38/p53 and c-jun.FOOD CHEMISTRY , 129, 1703-1709. 本人為通訊作者.

22.

Jen-Dong Hsu, Shao-Hsuan Kao, Ting-Tsz Ou, Yu-Jen Chen, Yi-Ju Li, Chau-Jong Wang (2011). Gallic acid Induces G2/M phase arrest of breast cancer cell MCF-7 through stabilization of p27(Kip1) attributed to disruption of p27(Kip1)/Skp2 complex. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 59, 1996-2003. 本人為通訊作者.

23.

Jiaan-Der Wang, Te-Kau Chang, Heng-Kueix Lin, Fang-Liang Huang, Chau-Jong Wang, Huei-Jane Li (2011). Reduced expression of transforming growth factor-β1 and correlated elevation of interleukin-17 and interleukin-γ in Pediatric patients with chronic primary immune thrombocytopenia. PEDIATRIC BLOOD & CANCER , 57, 636-640.

24.

Mon-Yuan Yang, Chien-Ning Huang, Kuei-Chuan Chan, Yi-Sun Yang, Chiung-Huei Peng, Chau-Jong Wang (2011). Mulberry leaf polyphenols possess antiatherogenesis effect via inhibiting LDL oxidation and foam cell formation.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 59, 1985-1995. 本人為通訊作者

25.

Mon-Yuan Yang, Yun-Ching Chang, Kuei-Chuan Chan, Yi-Ju Lee, Chau-Jong Wang (2011). Flavonoid-enriched extracts from Nelumbo nucifera leaves inhibits proliferation of breast cancer in vitro and in vivo. European Journal of Integrative Medicine , 153-163. 本人為通訊作者.

26.

Mu-Jang Lee, Han-Min Chen, Bor Show Tzang, Chiu-Wen Lin, Jer-Yuh Liu, Chau-Jong Wang, Shao-Hsuan Kao (2011). Ocimum gratissimum aqueous extract protects H9c2 myocardiac cells from H2O2-induced cell apoptosis through Akt signalling. Evidence-based Complementary and Alternative Medicine , In Press.

27.

Ting-Tsz Ou, Cheng-Hsun Wu, Jeng-Dong Hsu, Charng-Cherng Chyau, Huei-Jane Li and Chau-Jong Wang (2011). Paeonia lactiflora Pall inhibits bladder cancer growth involving phosphorylation of Chk2 in vitro and in vivo.JOURNAL OF ETHNOPHARMACOLOGY , 135, 162-172. 本人為通訊作者.

28.

Ting-Tsz Ou, Man-Jung Hsu, Kuei-Chuan Chan, Chieng-Ning Huang, Hsieh-Hsun Ho, Chau-Jong Wang (2011). Mulberry inhibits oleic acid-induced lipid accumulation via reduction of lipogenesis and promotion of hepatic lipid clearance. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE , 91, 2740-2748. 本人為通訊作者.

29.

Cheng-Hsun Wu, Mon-Yuan Yang, Kuei-Chuan Chan, Pei-Jun Cheng, Ting-Tsz Ou, Chau-Jong Wang (2010). Improvement in High-Fat Diet-Induced Obesity and Body Fat Accumulation by a Nelumbo nucifera Leaf Flavonoid-Rich Extract in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 58, 7075-7081. 本人為通訊作者.

30.

Cheng-Hsun Wu, Yuan-Wei Shin, Chun-Hua Chang, Ting-Tsz Ou, Chi-Chou Huang, Jeng-Dong Hsu, Chau-Jong Wang (2010). EP4 upregulation of ras signaling and feedback regulation of ras in human colon tisues and cancer cells. ARCHIVES OF TOXICOLOGY, 84, 731-740. 本人為通訊作者.

31

Chia-Wen Lo, Hui-Pei Huang, Kuei-Chuan Chan, Cheng-Hsun Wu, Chau-Jong Wang (2010). Hibiscus sabdariffa extract induced apoptosis of proliferating smooth muscle cell. JOURNAL OF FOOD BIOCHEMISTRY , 34, 549-563. 本人為通訊作者.

32.

Horng-Rong Chang, Hui-Pei Huang, Yu-Lin Kao, Sung-Lang Chen, Sheng-Wen Wu, Tung-Wei Hung, Jong-Da Lian, Chau-Jong Wang (2010). The suppressive effect of Rho kinase inhibitor, Y-27632, on oncogenic Ras/RhoA induced invasion/ migration of human bladder cancer TSGH cells. CHEMICOBIOLOGICAL INTERACTIONS , 83, 172-180. 本人為通訊作者.

33.

Hsieh-Hsun Ho, Chi-Sen Chang, Wei-Chi Ho, Sheng-You Liao, Cheng-Hsun Wu, Chau-Jong Wang (2010). Anti-metastasis Effects of Gallic Acid on Gastric Cancer Cells Involves inhibition of NF-κB activity and downregulation of PI3K/AKT/small GTPase signals. FOOD AND CHEMICAL TOXICOLOGY, 48 , 2508-2516. 本人為通訊作者.

34.

Hsieh-Hsun Ho, Li-Sung Hsu, Kuei-Chuan Chan, Hsiang-Mei Chen, Cheng- Hsun Wu, Chau-Jong Wang (2010). Extract from the leaf of nucifera reduced the development of atherosclerosis via inhibition of vascular smooth muscle cell proliferation and migration. FOOD AND CHEMICAL TOXICOLOGY, 48, 159- 168. 本人為通訊作者.

35.

Hsueh-Chun Wang, Dun-Hao Wu, Yun-Ching Chang, Yi-Ju Li, Cheng-Hsun Wu, Chau-Jong Wang (2010). Solanum nigrum Linn. water extract inhibits metastasis in mouse melanoma cells in vitro and in vivo. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 58, 11913-11923. 本人為通訊作者.Hsueh-Chun Wang, Dun-Hao Wu, Yun-Ching Chang, Yi-Ju Li, Cheng-Hsun Wu, Chau-Jong Wang (2010). Solanum nigrum Linn. water extract inhibits metastasis in mouse melanoma cells in vitro and in vivo. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 58, 11913-11923. 本人為通訊作者.

36.

Hsueh-Chun Wang, Pei-Jun Chung, Cheng-Hsun Wu, Kuang-Ping Lan, Mon-Yuan Yang, Chau-Jong Wang (2010). Solanum nigrum L. polyphenolic extract inhibits hepatocarcinoma cell growth by inducing G2/M phase arrest and apoptosis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 91, 178-185. 本人為通訊作者.

37.

Huei-Jane Lee, Chang-Che Chen, Chau-Jong Wang (2010). Water extracts from Neulumbo nucifera leaf reduced plasma lipids and atherosclerosis in cholesterol fed rabbits. JOURNAL OF FOOD BIOCHEMISTRY , 34, 779-795. 本人為通訊作者

38.

Hui-Hsuan Lin, Jing-Hsien Chen, Chau-Jong Wang (2010). Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus Sabdariffa Linne. CURRENT MEDICINAL CHEMISTRY , 18, 1245-1254. 本人為通訊作者.

39.

Jiaan-Der Wang, Ting-Tsz Ou, Wei-Chi Ho, Chau-Jong Wang, Te-Kau Chang, Huei-Jane Lee (2010). Platelet apoptosis resistance and increased CXCR4expression in pediatric patients with chronic immune thrombocytopenic purpura.THROMBOSIS RESEARCH , 126, 311-318. 本人為通訊作者.

40.

Kuei-Chuan Chan, Hsieh-Hsun Ho, Chiung-Huei Peng, Kuang-Ping Lan, Ming- Cheng Lin, Hsiang-Mei Chen, Chau-Jong Wang (2010). Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of Cyclin-Dependent Kinase. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 58, 2536-2542. 本人為通訊作者.

41.

Liang-Chih Liu, Chau-Jong Wang, Ching-Chih Lee, Sheng-Chi Su, Huei-Lin Chen, Jen-Dong Hsu, Huei-Jane Lee (2010). Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen-induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE , 90, 329-337.

42.

Mon-Yuan Yang, Chiung-Huei Peng, Kuei-Chuan Chan, Yi-Sun Yang, Chien- Ning Huang, Chau-Jong Wang (2010). The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting the lipogenesis and promoting the hepatic lipid clearance. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ,58, 850-859. 本人為通訊作者

43.

Mon-Yuan Yaug, Li-Sung Hsu, Chung-Huei Peng, Yi-Ju Li, Yuan-Shong Shi, Cheng-Hsun Wu, Chau-Jong Wang (2010). Polyphenol-rich extracts from Solanum nigrum attenuated PKC alpha-mediated migration and invasion of hepatocellular carcinoma cells. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 58, 5806-5814. 本人為通訊作者.

44.

Ting-Tsz Ou, Chau-Jong Wang, Yung-Shu Lee, Cheng-Hsun Wu, Huei-Jane Lee (2010). Gallic acid induces G2/M phase cell cycle arrest via regulating 14-3-3β release from Cdc42 and Chk2 activation in human bladder transitional carcinoma cells. MOLECULAR NUTRITION & FOOD RESEARCH , 54, 1781-1790. 本人為通訊作者.

45.

Tzi-Peng Yang, Hui-Ling Chiou, Ming-Chei Maa, Chau-Jong Wang (2010).Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression. CHEMICO-BIOLOGICAL INTERACTIONS , 183, 181-186. 本人為通訊作者.

46.

Yi-Chieh Lee, Hui-Hsuan Lin, Chin-Hsun Hsu, Chau-Jong Wang, Tai-An Chiang, Jing-Hsieh Chen (2010). Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY , 632, 23-32. 本人為通訊作者.

47.

Chien-Ning Huang, Kuei-Chuan Chan, Wei-Ting Lin,Shi-Li Su, Chau-Jong Wang, Chiung-Huei Peng (2009). Hibiscus sabdariffa inhibits vascular smooth muscle cell proliferation and migration induced by high glucose---amechanism involves connective tissue growth factor signals. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 57, 3073-3079. 本人為通訊作者.

48.

Erl-Shyh Kao, Jeng-Dong Hsu, Chau-Jong Wang, Su-Huei Yang, Su-Ya Cheng, Huei-Jane Lee (2009). Polyphenols extracted from Hibiscus sabdariffa L. inhibited lipopolysaccharide-induced inflammation by improving antioxidative conditime and regulating cyclooxygenase-2 expression. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73, 385-390.

49.

Erl-Shyh Kao, Tsui-Hwa Tseng, Huei-Jane Lee, Kuei-Chuan Chan, Chau-Jong Wang (2009). Anthoyanin extracts from Hibiscus attenuate oxidized LDL -mediated foam cell formation involving regulation of CD36 gene. CHEMICO BIOLOGICAL INTERACTIONS , 179, 212-218. 本人為通訊作者.

50.

Hui-Pei Huang, Yuan-Wei Shih, Cheng-Hsun Wu, Po-Ju Lai, Chi-Nan Hung, Chau-Jong Wang (2009). Inhhibitory effect of penta-acetyl geniposide on C6 glioma cells metastasis by inhibiting matrix metalloproteinase-2 expression involved in both the PI3K and ERK signaling pathways. CHEMICOBIOLOGICAL INTERACTIONS , 181, 8-14. 本人為通訊作者.

51.

Jeng-Dong Hsu, Shao-Hsuan Kao, Chang-Che Tu, Yi-Ju Li, Chau-Jong Wang (2009). Solanum nigrum L extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-trausferase and antioxidant enzymes. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 57, 8628-8634. 本人為通訊作者.

52.

Kuei-Chuan Chan, Hsieh-Hsun Ho, Chien-Ning Huang, Ming- Cheng Lin, Hsiang-Mei Chen, Chau-Jong Wang (2009). Mulberry leaf extract inhibits vascular smooth muscle cell migration involving a block of small GTPase and Akt/NF-κB signals. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 57, 9147-9153. 本人為通訊作者.

53.

Li-Kaung Liu, Fen-Pi Chou, Yi-Chen Chen , Charny-Cherng Chyau, Hsieh-Hsun Ho, Chau-Jong Wang (2009). Effect of Mulberry extracts on lipid hemeostasis in vitro and in vivo. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 57, 7605-7611. 本人為通訊作者.

54.

Ming-Cheng Lin, Shao-Hsuan Kao, Pei-Jun Chung, Kuei-Chuan Chan, Mon- Yuan Yang, Chau-Jong Wang (2009). Improvement for high fat diet-induce dhepatic injuries and oxidative stress by feavonoid-enriched extract from Nelumbo nucifera leaf. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 57, 5925-5932. 本人為通訊作者.

55.

Shou-Chieh Wang, Shiow-Fen Lee, Chau-Jong Wang, Chao-Hsin Lee, Wen-Chin Lee, Huei-Jane Lee (2009). Aqueous extract from Hibiscus sabdariffa Linnaeus ameliorate diabetic nephropathy via regulating oxidative status and Akt/Bad/14- 3-3γ in an experimental animal model. Evidence-based Complementary and Alternative Medicine , 1-9. 本人為通訊作者.

56.

Ting-Tsz Ou, Chau-Jong Wang, Guang-Uei Hung, Cheng-Hsun Wu, Huei- Jane Lee (2009). Aqueous extract of Shi-Liu-Wei-Liu-Qi-Yin induces G2/M phase arrest and apoptosis in human bladdercarcinoma cell via Fas and mitochondria pathway. Evidence-based Complementary and Alternative Medicine , 1-9. 本人為通訊作者.

57.

Wen-Chin Lee, Chau-Jong Wang, Yu-Hsin Chen, Jen-Dong Hsu, Su-Ya Cheng, Hong-Chen Chen, Huei-Jane Lee (2009). Polyphenol extracts from Hibiscus sabdriffa Linnaeus attenuate nephropathy in experimental type I dibetes. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 57, 2206-2210. 本人為第一作者.

58.

Hui-Mei Lin, Hsien-Chan Tseng, Chau-Jong Wang, Jing-Jing Lin, Chia-Win Lo, Fen-Pi Chou (2008). Hepatoprotective effect of SNE against CCL4-induced oxidative damage in rats. CHEMICO-BIOLOGICAL INTERACTIONS , 171,283-293.

59.

Hui-Pei Huang, Yung-Wei Shih, Kai-Xun Huang, Chan-Jong Wang (2008).Chemopreventive effect of Mulberry anthocyanins on the melanoma metastasis involved in Ras and PI3K-Akt pathway. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY , 56, 9286-9293. 本人為通訊作者.

60.

Jing-Hsien Chen, Hui-Hsuan Lin, Tai-An Chiang, Hsieh-Hsun Ho, Yi-Chieh Lee, Chau-Jong Wang (2008). Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion and metastasis via iNOS-mediated MMP-2 production. TOXICOLOGICAL SCIENCES, 106, 364-375. 本人為通訊作者.

61.

Jing-Hsien Chen, Hui-Hsuan Lin, Tai-An Chiang, Hsieh-Hsun Ho, Yi-Chieh Lee, Chau-Jong Wang (2008). Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion and metastasis via iNOS-mediated MMP-2 production. TOXICOLOGICAL SCIENCES, 106, 364-375. 本人為通訊作者.

62.

Kuei-Chuan Chan, Chau-Jong Wang, Hsieh-Hsun Ho, Hsiang-Mei Chen, Chien-Ning Huang (2008). Simvastatin inhibits cell cycle progression in glucosestimulatedproliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53. PHARMACOLOGICAL RESEARCH, 58, 247-256. 本人為第一作者.

63.

Li-Kauang Liu, Huei-Jane Lee, Yuan-Wei Shih, Charng-Cherng Chyau, Chan-Jong Wang (2008). Mulberry anthocyanin extracts inhibit LDL oxidation and macrophage-derived foam cell formation induced by oxidative LDL. JOURNAL OF FOOD SCIENCE , 73, 113-121. 本人為通訊作者.

64.

Wei-Jiunm Lee, Wen-Kang Chen, Chau-Jong Wang, Wea-Lung Liu, Tsui- Hwa Tseng (2008). Apigenin inhibits HGF-promoted invasive grouth and metastasisinvolving blocking PI3K/AKT pathway and β4 integrin function in MDA-MB- 231 breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY, 226,178-191.

(B) CONFERENCE PAPER

1.

Chang-Che Chen, Jeng-Dong Hsu, Sen-Fa Wang, Men-Yuan Yang, Erh-Shyh Kao, Chau-Jong Wang (2012). Hibiscus sabdariffa extracts (HSE) inhibit atherosclerosis in cholesterol-fed rabbit. The Seventeenth Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

2.

Chang-Chieh Tang, Yu-Hsien Tang, Mon-Yuan Yang, Chau-Jong Wang (2012). Mulberry water extracts attenuate the fatty metamorphosis in ethanol diets-fed mice model . The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者

3.

Chi-Nan Hung, Chau-Jong Wang, Hui-Pei Huang (2012). Sulforaphane inhibits smooth muscle cell proliferation and migration by reduction of MMP-9 activity via Ras/PI3K pathway. The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC.

4.

Ching-Chun Chen, Chun-Hua Chang, Chau-Jong Wang (2012). Anti-matastatic effect of H. polyphenol-rich extracts (HPE) on human colon cancer. The71st Annual Meeting of the Japanese Cancer Association, Sapporo, Japan. 本人為通訊作者.

5.

Chun-Hua Chang, Mon-Yuan Yang, Chau-Jong Wang (2012). Nelumbo Nucifera Leaf extract (NLE) suppresses angiogenesis through the inhibition of CTGF in human breast cancer. The71st Annual Meeting of the Japanese Cancer Association, Sapporo, Japan. 本人為通訊作者.

6.

Chun-Hua Chang, Mon-Yuan Yang, Li-Chu Chen, Chau-Jong Wang (2012). Nelumbo nucifera leaf extract (NLE) inhibits angiogenesis in human breast cancer. The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

7.

Hsing-You Jao, Chau-Jong Wang, Huei-Jane Lee (2012). Effect of Mulberry water extracts Improve Osteoporosis of Ovariectomic Rat. International Conference and Exhibition on Nutraceuticals and Functional Foods, Kona,Hawaii. USA.

8.

Hui-Pei Huang, Sz-Ya Shao, Chi-Nan Hung, Chau-Jong Wang (2012). Mulberry anthocyanins inhibit tumor-associated macrophage enhanced human gastric cancer migration and angiogenesis. The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

9.

Jing-Hsien Chen, Chau-Jong Wang, Chen-Chien Wang, Chia-Liang Lin, Hui-Hsuan Lin (2012). Hibiscus sabdariffa leaf reduces the development of atherosclerosis via inhibition of LDL oxidation and foam cell formation. The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC.

10.

Mon-Yuan Yang, Chau-Jong Wang (2012). Mulberry leaf extract ameliorate obesity induced by high-fed diet in C57B1/6 mice. The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

11.

Sz-Ya Shao, Chau-Jong Wang, Hui-Pei Huang (2012). Mulberry anthocyanins induce cell cycle arrest and apoptosis in leukemia WEHI-3 cells. The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC.

12.

Wan-Ling Zeng, Chau-Jong Wang, Yun-Ching Chang (2012). Anthocyanins: Evaluation of the in vitro. The 27th Joint Annual Conference of Biomedical Science, Taipei, ROC.

13.

Chau-Jong Wang, Ya-Ping Lin, Huei-Jane Lee (2011). Mulberry water extract improve osteoporosis in ovariectomic rat. International Conference on Food Factors, Taipei, ROC. 本人為第一作者.

14.

Chi-Nan Hung, Hui-Pei Huang, Chau-Jong Wang (2011). Chemoinhibitory Effect of sulforaphane on Smooth muscle cell Proliferating and Migration Involved in the Ras/PI3K Pathway. International Conference on Food Factors, Taipei, ROC. 本人為通訊作者.

15.

Chun-Hua Chang, Jih-Shin Peng, Mon-Yuan Yang, Chau-Jong Wang (2011). Protection effect of mulberry extract in STZ inducing rat liver injury involves attenuation hepatic lipid accumulation. The 26th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

16.

Chun-Hua Chang, Mon-Yuan Yang, Chau-Jong Wang (2011). Nuciferine Leaf extract (NLE) inhibits human breast cancer growth by suppressing fatty acid synthase and Akt signaling. 70th Annual Meeting of the Japanese Cancer Association, Nagoya, Japan. 本人為通訊作者.

17.

Hsing-You Jao, Chau-Jong Wang, Xiu-Juan Zhan, Huei-Jane Lee (2011). Mulberry water extracts ameliorate diabetic cataract in type diabetes animal model. International Conference on Food Factors, Taipei, ROC.

18.

Hui-Hsuan Lin, Chau-Jong Wang, Jing-Hsien Chen (2011). Apoptotic effect of Hibiscus sabdariffa leaf on human prostate cancer cells through both intrinsic and extrinsic pathways. International Conference on Food Factors, Taipei, ROC.

19.

Hui-Pei Huang, Chau-Jong Wang (2011). The mechanism of MACs inhibiting macrophage enhanced gastric cancer migration and angiogenesis. International Conference on Food Factors, Taipei, ROC. 本人為通訊作者.

20.

Hui-Pei Huang, Chau-Jong Wang (2011). Cyanidine-rich Mulberry anthocyanins induces apoptosis and suppresses growth in nude mice xenografts. The 26th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

21.

Hui-Pei Huang, Horng-Rong Chang, Chau-Jong Wang (2011). Aristolochic acid enhances the invasion/migration of human urothelial cancer TSGH cells. The 26th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

22.

Hui-Pei Huang, Yun-Ching Chang, Chi-Nan Hung, Chau-Jong Wang (2011). Cyanidine-rich Mulberry anthocyanins inhibit the AGS gastric cancer cell growth in vitro and xenograft mice via p38/p53 and c-jun signaling. International Conference on Food Factors, Taipei, ROC. 本人為通訊作者.

23.

Jeng-Rong Lin, Cheng-Ying Wu, Hsiang-Yu Chang, Jing-Hsien Chen, Chau- Jong Wang, Jen-Kun Lin, Hui-Hsuan Lin (2011). High Glucose-Induced Insulin Signaling Blockade in Human HepG2 Hepatoma Cells. The 26th Joint Annual Conference of Biomedical Science, Taipei, ROC.

24.

Jing-Hsien Chen, Chau-Jong Wang, Hui-Hsuan Lin (2011). Inhibition of Benzo(a)pyrene-Induced Forestomach Tumors by Hibiscus Sabdariffa Linne. The 26th Joint Annual Conference of Biomedical Science, Taipei, ROC. 25. Jing-Hsien Chen, Chau-Jong Wang, Hui-Hsuan Lin (2011). Chemopreventive effects of Hibiscus sabdariffa Linne leaf extract on prostate cancer cells through apoptosis induction. The 26th Joint Annual Conference of Biomedical Science,Taipei, ROC.

25.

Mon-Yuan Yang, Chau-Jong Wang (2011). Morus alba L. leaves extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. The 26th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

26.

Mon-Yuan Yang, Li-Chu Chen, Chau-Jong Wang (2011). Polyphenol-enriched extracts from Nelumbo Nucifera leave suppress the migration and invasion in breast cancer cell. 70th Annual Meeting of the Japanese Cancer Association,Nagoya, Japan. 本人為通訊作者.

27.

Mon-Yuan Yang, Kuei-Chuan Chan, Chau-Jong Wang (2011). Mulberry leaf polyphenols possess antiatherogenesis effect via inhibiting VAMC proliferation and migration. International Conference on Food Factors, Taipei, ROC. 本人為通訊作者

28.

Mon-Yuan Yang, Pei-Jun Chung, Chau-Jong Wang (2011). Solanum nigrum L. polyphenolic extract suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. The 26th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

29.

Xiu-Juan Zhan, Hsing-You Jao, Chau-Jong Wang, Huei-Jane Lee (2011). Mulberry water extract ameliorate diabetes complicated nephropathy and osteoporosis in animal model. International Conference and Exhibition on Nutraceuticals and Functional Foods, Sapporo, Japan.

30.

Chih-Ying Wang, Chau-Jong Wang, Huei-Jane Lee (2010). The ameliorative effect of apple polyphenol on streptozotocin induced diabetic nephropathy. The 25th Joint Annual Conference of Biomedical Science, Taipei, ROC.

31.

Chin-Hsing Feng, Chau-Jong Wang, Fu-Yuan Hsueh, Tung-hsi Yu (2010). Resveratrol protect the brain sod sustained epileptic activity in the pilocarpineinduced changes in the next. The 25th Joint Annual Conference of Biomedical Science, Taipei, ROC.

32.

Huei-Jane Lee, Chau-Jong Wang (2010). Gallic acid induced apoptosis and autophagy in bladder cancer cell. AACR 101st Annual Meeting, USA. 本人為通訊作者.

33.

Hui-Hsuan Lin, Jing-Hsien Chen, Chau-Jong Wang (2010). Induction of apoptosis in the lung tissue from rats to cigarette smoke involves p38/JNK MAPK pathway. The 25th Joint Annual Conference of Biomedical Science , Taipei, ROC. 本人為通訊作者.

34.

Man-Jung Hsu, Mon-Yang Yang, Chau-Jong Wang (2010). Mulberry polyphenolic components reduce hepatic lipid accumulation via inhibiting lipogenesis and hepatic clearance. The 25th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

35.

Yun-Ching Chang, Chau-Jong Wang (2010). Inhibitory effects of the water extract of Nelumbo Nucifera leaf on human breast carcinoma MCF-7 cells in vitro and in vivo. AACR 101st Annual Meeting, USA. 本人為通訊作者.

36.

Cheng-Hsun Wu, Chun-Huz Chang, Yuan-Wei Shin, Ting-Tsz Ou, Chi-Chou Huang, Jeng-Dong Hsu, Chau-Jong Wang (2009). EP4 upregulation of ras signaling and feedback regulation of ras in human colon tissue and cancer cells. The 5th International Congress of Asian Society of Toxicology, Taipei, ROC. 本人為通訊作者.

37.

Chen-Shu Chun, Yun-Ching Chang, Chau-Jong Wang (2009). Mulberry leave polyphenols reduced lipid accumulation in hepatocytes. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

38.

Chin-Hsing Feng, Chau-Jong Wang, Mei-Lin Shen, Ching-Huei Lin, Hsieh Pei-F (2009). Effect of Resveratrol Prevents Neuronal Damage in Pilocarpine-induced Status Epilepticus. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC.

39.

Chin-Ya Wang, Mon-Yuan Yang, Ming-Chen Lin, Chau-Jong Wang (2009). Rutin-rich Nelumbo Nucifera leaves extract diminish heaptic lipids accumulation through AMPK phosphorylation and PPARγ expression. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

40.

Dun-Hao Wu, Cing-Yuan Chen, Chau-Jong Wang (2009). Chemoinhibitory effect of solanum nigrum water extracts on the angiogenesis and metastasis in B16 melanoma cells. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

41.

Horng-Rong Chang, Hui-Pei Huang, Jong-Da Lian, Sheng-Wen Wu, Tung-Wei Hung, Chau-Jong Wang (2009). Aristolochic acid enhances the invasion/migration of human urothelial cancer TSGH cells. Annual Conference of Taiwan Society Nephrology, Taipei, ROC. 本人為通訊作者.

42.

Hui-Hsuan Lin, Jing-Hsien Chen, Chau-Jong Wang (2009). Hibiscus polyphenol rich extract induces G1 phase cell cycle arrest in human gastric cells. The 24th  Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

43.

Jing-Hsien Chen, Hui-Hsuan Lin, Tai-An Chiang, Yi-Chieh Lee, Chau-Jong Wang (2009). Gaseous Nitrogen Oxide Promotes Human Lung Cancer Cell Line A549 Migration amd Invasion via JNK1/p38 MAPK and PI3K-Akt pathways. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

44.

Sheng-You Liao, Hsieh-Hsun Ho, Wei-Chi Ho and Chau-Jong Wang (2009). Gallic acid inhibit gastric cancer metastasis via inhibition of RHOB expression and downregulation of migration signals. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

45.

Shu-Ling Huang, Mon-Yuan Yang,Chung-Chia Liao, Chau-Jong Wang (2009). Caffeic acid regulates binding protein-1c expression and its downstream target genes. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC.本人為通訊作者.

46.

Ting-Tzu Ou, Huei-Jane Lee, Chau-Jong Wang (2009). Gallic acid induced cell cycle arrest at G2/M phase via regulating checkpoint kinase 1-mediated phosphorylation of Cdc25C in bladder cancer cell. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

47.

Yi-Ming Kuo, Chao-Hsin Lee, Chau-Jong Wang, Huei-Jane Lee (2009). Aqueous extract from solanum nigrumi ameliorates neurodegeneration in experimental parkinson disease. The 24th Joint Annual Conference of Biomedical Science, Taipei, ROC.

48.

Chang-Che Tu, Mon-Yuan Yang, Yi-Ju Lee, Jeng-Dong Hsu, Chau-Jong Wang (2008). Solanum nigrum L. extracts inhibits AAF-induced liver cirrhosis and hepatocellular carcinoma in rats. The 23th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

49.

Hui-Hsuan Lin, Jing-Hsien Chen, Chau-Jong Wang (2008). Protocatechuic acid inhibits gastric cancer cell invasion by suppressing Ras-mediated Akt downregulation of RhoB, and matrix metalloproteinase-2 production. The 23th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

50.

Hui-Pei Huang, Chau-Jong Wang (2008). The chemopreventive effect of Mulberry anthocyanins on the melanoma metastasis involved in Ras/Akt pathway. The 23th Joint Annual Conference of Biomedical Science, Taipei,ROC. 本人為通訊作者.

51.

Jhe-Hong Jian, Chau-Jong Wang, W.T. Lee, Huei-Jane Lee (2008). The effect of Hibiscus sabdariffa linnaeus extract on diabetes induce ophthalmopathy in streptozotocin-treated rats. The 23th Joint Annual Conference of Biomedical Science, Taipei, ROC.

52.

Lian-Ru Siao, Chau-Jong Wang, Huei-Jang Lee (2008). Study on the cardiovascular disease inhibitory effect on Solanum nigrum extracts. The 23th Joint Annual Conference of Biomedical Science, Taipei, ROC.

53.

Li-Kauang Liu, Chang-Che Chen, Chau-Jong Wang (2008). Mulberry water extracts decrease hypercholesteremia in hypercholesteremic hamsters and mediate the introcellular cholesterol homeostais in human cells. The 23th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

54.

Mon-Yuan Yang, Ya-Von Jeng, Pei-Jun Chung, Chau-Jong Wang (2008). Nelumbo nucifera leaves extracts suppresses breast cancer development in vivo and in vitro. The 23th Joint Annual Conference of Biomedical Science, Taipei,ROC. 本人為通訊作者.

55.

Pei-Jun Chung, Mon-Yuan Yang, Chau-Jong Wang (2008). Solanum nigrum L. polyphenol extracts inhibit cell growth and induce apoptosis in human hepatocarcinoma cells. The 23th Joint Annual Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

56.

Yuan-Wei Shih, P.T. Chen, Ya-Von Jeng, Chau-Jong Wang (2008). α-chaconinereduced metastasis involves a PI3K/Akt signaling pathway with downregulation of NF-κB in human lung adenocarcinoma A549 cells. The 23th Joint Annua Conference of Biomedical Science, Taipei, ROC. 本人為通訊作者.

(C) Patent

1.

專利名稱: 洛神花萃取物用於製備腦心血管病變藥物的用途
國別: 大陸
專利號碼: ZL 011 42452,4

2.

專利名稱: 洛神花萼萃取物用於製備抑制腦心血管病變之藥物用途
國別: 台灣
專利號碼: 發明第I 38882

3.

專利名稱: METHOD TO COUNTER OXIDATION OF LDL,DECREASE TRIGLYCERIDE OR CHOLESTEROL AND INHIBIT ATHEROSCLEROSIS
國別: 美國
專利號碼: US 6,849,278 B2

4.

專利名稱: EXTRACTS OF SACRED WATER LOTUS FOR THE TREATMENT OF CANCER
國別: 美國
專利號碼: US 7,662,413 B2

5.

專利名稱: 洛神花青素抗血癌之用途
國別: 美國
專利號碼:US 8,007,835 B2

6.

專利名稱: 治療癌症之水萃荷葉萃取物
國別:台灣
專利號碼:發明第I406667



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